Background and objective: Non-steroidal anti-inflammatory drugs (such as diclofenac1) had been widely prescribed for the treatment of different types of pain; however. they are not devoid of adverse effects. Therefore. synthesis of new bio-isosteric analogs4a-e of diclofenac1 with greater COX II selectivity and less gastrointestinal side effect is demanded. https://excellentphoto.shop/product-category/pro-audio/